Niacinamide Vitamin B3

aging-vs-longevity-lv4

Firmness / AgingBrighteningBarrier

INCI: Niacinamide (Vitamin B3)

Effect

Wrinkle improvement, melanin suppression, barrier strengthening, NAD+ precursor

Mechanism

NAD+ replenishment via salvage pathway → SIRT1 activation. NF-κB suppression. Melanosome transfer inhibition

Typical concentration

2-5% (MHLW approved)

Onset

Barrier: 2-4 weeks. Brightening: 8-12 weeks. Wrinkles: 12+ weeks

Cautions

Irritation at high concentrations (10% or above)

Evidence & references

Bissett et al. (2005) [PubMed], Hakozaki et al. (2002) [PubMed]

Journal

Related Journal

Skin-Concern SolutionsFor Those Who See No Change from Brightening Products -- The Real Causes of Dull Skin Skin-Concern SolutionsFor Those Who See No Results from Expensive Serums -- Why Price Doesn't Equal Effectiveness What “Suits Your Skin” MeansThe scientific foundation of personalized skincare Care Guides by ConcernDark spot and dullness care — the mechanism of melanin and effective ingredients Care Guides by ConcernPore and acne care — the 3 factors of sebum, keratinization, and inflammation Skincare FundamentalsThe Correct Skincare Order — Why This Sequence Matters The Complete Peptide GuidePeptide effective concentrations and the penetration challenge The Complete Vitamin C GuideVitamin C x other ingredients -- synergies and contraindications Anti-Aging vs LongevityMost anti-aging ingredients are "symptomatic treatment"—the difference from fundamental care Anti-Aging vs LongevityWhy "fighting back" fails—from the perspective of cellular senescence and SASP

This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.

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